Join us for the February Characterization User Forum focused on CryoEM capabilities.
DATE: Wednesday, February 12, 2025
TIME: 4:00 p.m. — 5:00 p.m. ET
LOCATION: 12-0168 (MIT.nano basement teaching space)
- Get to know your Characterization community.
- Bring questions about your data.
- Share your feedback in a user-led town hall.
- Stay up-to-date with facility news.
- Food and drink will be provided.
Each user forum also includes a spotlight talk by a graduate student. The February forum will feature:
Towards automated model-free analysis of cryo-EM volume ensembles with SIREn
Speaker
Maria Carreira
Graduate Student
Davis Group, Department of Biology, MIT
Abstract
The talk will introduce SIREn (Subunit Inference from Real-space Ensembles), a novel computational tool to automate the analysis of heterogeneous volume ensembles from cryo-EM, as well as a 3D-CNN (Convolutional Neural Network) that predicts per-volume binarization thresholds. During the talk, Carreira will present benchmarks and the applications of SIREn to real, highly heterogeneous single-particle and cryo-ET datasets.
Biography
Maria completed her undergraduate studies in Biochemistry at University College London (UCL), where she worked on the effects of aberrant PI3K signaling on microtubule dynamics. In 2021, Maria joined the MIT Biology program and later, the Davis lab, where she is working on new computational methods to further resolve structural heterogeneity using cryo-EM.