8th Semi-Annual New England CryoEM Symposium—June 13 & 14

The 8th Semi-Annual New England CryoEM Symposium will highlight innovative projects that use CryoEM/ET methods. Hosted by MIT.nano and MIT Biology, this symposium is a great opportunity for graduate students and postdoctoral trainees to present their work.

June 13-14, 2022
Virtual on Zoom

>>Register

Agenda

June 13, 2022

Time Event
12:00 - 12:10 PM Opening remarks: Joey Davis, Massachusetts Institute of Technology
   
12:10 - 2:10 PM Session I: Method Development
Moderator: Lucas Farnung, Harvard Medical School
   
12:15 - 12:35 PM Barrett Powell, Massachusetts Institute of Technology
"TomoDRGN: resolving heterogeneous protein complexes in situ using cryo-ET and deep learning"
12:35 - 12:55 PM Fanis Grollios, Thermo Fisher Scientific
“Thermo scientific Smart EPU and Tomography 5: Making Cryo-EM workflows easier and more efficient”
12:55 - 1:00 PM Lightning talk: Laurel Kinman, Massachusetts Institute of Technology
“Automating the Structural Analysis of Large Ensembles of 3D Density Maps”
1:00 - 1:10 PM Break
1:10 - 1:30 PM Yilai Li, University of Michigan
"Optimized path planning on cryo-EM samples with reinforcement learning"
1:30 - 1:50 PM Max Prigozhin, Harvard University
“Multicolor and time-resolved electron microscopy”
1:50 - 1:55 PM Lightning talk: Simon Merminod, Harvard University
“Time-resolved cryo-vitrification”
1:55 - 2:10 PM Breakout rooms with speakers
2:10 - 2:20 PM Break
   
2:20 - 4:00 PM Session II: Protein / Nucleic Acid Systems
Moderator: Ashish Kumar, Yale University
   
2:25 - 2:45 PM Martin Filipovski, Harvard Medical School
“Structural basis of nucleosome retention during transcription elongation”
2:45 - 3:05 PM Alexandra Deaconescu, Brown University
“Molecular Determinants of dsDNA Translocation by the Transcription-Repair and Evolvability Factor, Mfd”
3:05 - 3:25 PM Jung-Un Park, Cornell University
“Mechanistic details of CRISPR-associated transposon recruitment and integration revealed by Cryo-EM”
3:25 - 3:45 PM Da Cui, City University of New York
“AlphaFold2 sheds light on the mechanism of the DEAH-box helicase DHX29 during translation initiation”
3:45 - 4:00 PM Breakout rooms with speakers
4:00 - 4:10 PM Closing remarks: Joey Davis, Massachusetts Institute of Technology

 

June 14, 2022

Time Event
12:00 - 12:10 PM Opening remarks: Seychelle Vos, Massachusetts Institute of Technology
   
12:10 - 1:35 PM Session III: Protein Complexes / Regulatory Mechanisms
Moderator: Alireza Ghanbarpour, Massachusetts Institute of Technology
   
12:15 - 12:35 PM Sheng Shu, Yale University
“Regulatory Mechanisms of Lipopolysaccharide Synthesis in Escherichia coli”
12:35 - 12:55 PM Shawn Egri, UMass Chan Medical School
“Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism”
12:55 - 1:15 PM Sheena Vasquez, Massachusetts Institute of Technology
“Cryo-EM Structure Determination of Met18, a Scaffold Protein for Iron-Sulfur Protein Maturation”
1:15 - 1:20 PM Lightning talk: Katie Digianantonio, Arvinas
“Novel E3 ligase structure informs drug discovery”
1:20 - 1:35 PM Breakout rooms with speakers
1:35 - 1:45 PM Break
   
1:45 - 2:50 PM Session IV: Industry Career Discussion
Moderator: Xun Bao, Massachusetts Institute of Technology
   
1:50 - 2:35 PM Career panel discussion:
  • Bharat Reddy, Rectify Pharma (a small biotech with Series A funding)
  • Claudio Perez, Generate Biomedicines (a mid-size biotech with Series B funding)
  • Jay Chodaparambil, Biogen (a large biotech, publicly traded)
  • Giovanna Scapin, NanoImaging Services (contract research operation)
2:35 - 2:50 PM Breakout rooms with panelists
2:50 - 3:00 PM Break
   
3:00 - 4:10 PM Session V: Visualizing Conformational Changes and Steps within Catalytic Cycles
Moderator: Kelsey Miller, Massachusetts Institute of Technology
   
3:05 - 3:25 PM Michelle Fry, Massachusetts General Hospital
“A structural view of the catalytic cycle of a TA protein Chaperone get3”
3:25 - 3:45 PM Christopher Gisriel, Yale University
“High-resolution cryo-electron microscopy structure of photosystem II from the mesophilic cyanobacterium, Synechocystis sp. PCC 6803”
3:45 - 3:50 PM Lightning talk: Gisele Andree, Massachusetts Institute of Technology
“Structural Investigation of Allosteric Regulation in Class III Ribonucleotide Reductases”
3:50 - 3:55 PM Lightning Talk: Mary Andorfer, Massachusetts Institute of Technology
“Snapshots of Glycyl Radical Enzymes Obtained by Cryo-Electron Microscopy Allow for Visualization of Conformational Changes due to Subunit Subtraction”
3:55 - 4:10 PM Breakout rooms with speakers
4:10 - 4:20 PM Closing remarks: Seychelle Vos, Massachusetts Institute of Technology

 

Questions? Contact CryoEMSymposium@mit.edu.

Background image courtesy of Prof. Seychelle Vos.